The first closed-loop affective neurotechnology

Designing the next human emotions.

ReWire combines personalized content with brain and body stimulation to give people access to emotional states on demand, and to recover the ones they have lost.

The vision

ReWire designs synthetic emotions and expands the range of what humans can feel. For ten years our team studied how emotions arise in the brain and the body to build an engine that creates them on demand. The first emotion we engineered is aesthetic chills, the feeling of cold down your spine when you listen to music or engage with films. We partner with world class institutions to help people reach their goals, restore function in psychiatry, and discover new forms of experience.

How it works

The engine.

A proprietary stack that predicts who will respond, triggers the response, amplifies it through the body, and engages the neural circuit directly.

01Personalization
Predict

We know what will move you, before you press play.

A multimodal model trained on thousands of labeled chills responses predicts how each person reacts to a given stimulus, reaching AUC 0.76 on held-out data.

Schoeller et al., PNAS Nexus, 2024
02Content
Induce

We create the content that gives you chills.

Our classifier finds the exact moments that deliver chills in any audio or video. We optimize existing content to raise the response, and generate new content from scratch.

Current induction rate · 74%
03Wearable
Augment

Amplify the response through the body.

A suite of closed-loop interoceptive wearables raises the magnitude and reliability of the bodily response. Currently under clinical investigation.

Schoeller et al., Neurosci. Biobehav. Rev., 2024
04Neural
Target

Engage the reward circuit directly.

Closed-loop neuromodulation paired with experiential stimuli, through our own pipeline of devices and protocols that engineer specific neural states.

Modalities · tFUS · tDCS · rTMS · VNS
5,000+
Chills engineered to date across our studies and sessions
74%
Chills induction rate from our generative engine
70%
Up to this reduction in anhedonia in early feasibility work
60+
Peer-reviewed publications behind the platform
Products

What we build.

ReWire is available as an app, through clinicians, at specific locations, and as an engine we license to platforms.

01 · App Early access

The ReWire app.

Personalized sessions that deliver chills on demand, for everyday emotional wellness. The app is opening soon to its first users.

Get early access
02 · Clinical Clinician supervised

Clinical therapeutics.

A digital therapeutic for depression and anhedonia, used by patients together with their clinicians, including in clinical trials.

Sign up as a clinician
03 · In person Locations

Activations.

ReWire is accessible in person at specific locations, through immersive installations and live experiences built around the engine.

04 · Platforms Licensing available

Commercial licensing.

We detect chills in any audio or video, optimize content to raise the response, and generate new content. Studios, platforms, and brands can license the engine.

Commercial inquiries
As featured in
Founders02
Felix Schoeller
Felix Schoeller, PhD
Chief Executive Officer · ReWire Neurotechnologies
Felix Schoeller

Felix is a founder and neuroscientist who has built his career bridging the gap between affective neuroscience research and market-ready mental health technologies. He has founded three ventures at the intersection of emotional AI, neurotechnology, and clinical applications.

He is the creator of the first closed-loop system for inducing aesthetic chills, and the inventor of BeSound, a wearable gesture-sonification device for PTSD currently under clinical investigation at AP-HP (RCT SONICUMP). He co-invented Huxley with Linc Gasking — billed as the first generative AI artist by Rolling Stone — whose AI-generated music video for Duran Duran premiered at the 2021 Billboard Music Awards. His most recent venture, Lucy, is a voice-based simulation for training psychedelic therapists, trained on thousands of anonymized real-world session transcripts.

PhD in Cognitive Science from the École des Hautes Études en Sciences Sociales (EHESS), Paris, with postdoctoral affiliations at MIT, INSERM, and the Gonda Multidisciplinary Brain Research Center. Author of 60+ peer-reviewed publications across top-tier journals. Research supported by Joy Ventures, the European Commission, and the French Ministry of Defense.

Nicco Reggente
Nicco Reggente, PhD
Director of Neuroscience · ReWire Neurotechnologies
Nicco Reggente

Nicco is a cognitive neuroscientist whose work spans multivariate neuroimaging, closed-loop neurotechnology, and computational prediction of treatment response. PhD in Cognitive Neuroscience from UCLA.

Co-founder and Research Director of the Institute for Advanced Consciousness Studies (IACS) in Los Angeles, where he directs studies on consciousness, emotion, and the neural basis of peak experience.

Lead author on a PNAS paper using resting-state functional connectivity to predict treatment response in obsessive-compulsive disorder — work that informs the personalization engine inside the ReWire platform.

Advisors03
Diego A. Pizzagalli
Diego A. Pizzagalli, PhD
University of California, Irvine · Noel Drury Institute
Diego A. Pizzagalli

Diego Pizzagalli is a global authority on the neurobiology of anhedonia and reward processing, ranking among the most cited researchers in the field of depression. As the Founding Director of the Noel Drury, M.D. Institute for Translational Depression Discoveries at UCI and the former Director of the Center for Depression, Anxiety and Stress Research at Harvard Medical School, his foundational research has defined the field's understanding of reward system dysfunction.

Dr. Pizzagalli is the creator of the Probabilistic Reward Task (PRT), the gold-standard instrument used to quantify blunted reward learning in clinical populations, a core mechanism that the ReWire platform aims to address. He is a primary co-author with the ReWire founders on peer-reviewed publications establishing the mechanism behind the platform.

Kim C. Willment
Kim C. Willment, PhD
Harvard Medical School · Brigham and Women's Hospital
Kim C. Willment

Dr. Kim Willment is a board-certified neuropsychologist, assistant professor at Harvard Medical School, and Founder and Director of the RENEW Program (Resilience through Neurological and Emotional Wellness) at Brigham and Women's Hospital. She has spent two decades pioneering the clinical implementation of non-pharmacologic interventions for neurological populations.

Her expertise in neuropsychological assessment and rehabilitation is instrumental in translating ReWire's embodied digital therapeutics from laboratory protocols into scalable, real-world clinical workflows. Dr. Willment's work focuses on restoring neurological health through resilience-building, directly complementing ReWire's mission to engage the whole human body in mental health treatment.

She believes ReWire is a powerful tool for both patients and clinicians that helps people reconnect with more expansive, adaptive ways of experiencing themselves and the world.

Adam McGuire
Adam McGuire, PhD
University of Texas at Tyler · Clinical Psychology PhD Program
Adam McGuire

Dr. Adam McGuire is an Associate Professor of Psychology, a Licensed Clinical Psychologist, and a pioneer researcher on veterans' mental health and trauma-related disorders. As a federally funded Principal Investigator, he leads innovative clinical trials on positive-emotion induction, specifically "moral elevation," to treat trauma and comorbid depression.

Dr. McGuire's deep expertise in digital affect exposure and rigorous clinical trial design for high-acuity psychiatric conditions ensures that ReWire's embodied therapeutics are grounded in the highest standards of evidence-based practice for complex mental health populations.

Get involved

Get access to ReWire.

Sign up for early access to the app, register as a clinician, or license the engine for your platform.